Phytochemical and Biological Effects of Newbouldia laevis : A Review

Khaled Rashed

doi:10.32439/ps.v4i5.208-213

Authors

Khaled Rashed

DOI:

https://doi.org/10.32439/ps.v4i5.208-213

Keywords:

Newbouldia laevis, Chemical compounds, Plants, Bioactivities

Abstract

Newbouldia laevis (L) plant is a medium sized angiosperm and it is from Bignoniaceae family. In Nigeria vernacular, it is called Aduruku. It is popularly known as the tree of life or fertility tree in Nigeria. The plant has been found to be effective in the treatment of elephantiasis, dysentery, rheumatic swellings, syphilis, constipation, pile and as a vermifuge to round worms. It has also been found useful for earache, sore feet, chest pain, epilepsy and children's convulsion. Previous chemical studies proved that it has flavonoids, tannins, terpenes, phenolics, saponins, cardiac glycosides and alkaloids.

References

Agbafor K. N, Ezeali C. (2015) Effects of Leaf and Root Extracts of Newbouldia laevis on Hepatic and Renal Systems in Albino Rats. J Pharm Chem Biol Sci ; 3(3):367-372.

Akande E. B., B. O. Oladejo , M. K. Oladunmoye and T. F. Abodunrin (2020) Asian Plant Research Journal, 4(1): 26-34. DOI: https://doi.org/10.9734/aprj/2020/v4i130077

Akerele JO, Ayinde BA, Ngiagah J. (2011) Phytochemical and antibacterial evaluations of the stem bark of Newbouldia leavis against isolates from infected wounds and eyes. Tropical Journal of Pharmaceutical Research. 2011;10(2):211-218. DOI: https://doi.org/10.4314/tjpr.v10i2.66566

Aladesanmi AJ, Nia R, Nahrstedt A. (1998) New pyrazole alkaloids from the root bark of Newbouldia laevis, Planta Med. 1998;64: 90-91. DOI: https://doi.org/10.1055/s-2006-957380

Arbonnier, M. (2004). Trees, Shrubs and Lianas of West African Dry Zones. CIRAD, Margraf Publishers GMBH MNHN, Cote d’Ivorie. p. 194..

Bartke, N.; Hannun, Y. A., (2009) Bioactive sphingolipids: metabolism and function. Journal of Lipid Research 2009, 50 (Supplement), S91–S96. DOI: https://doi.org/10.1194/jlr.R800080-JLR200

Bosha JA, Sule S, Asuzu IU. (2019) Antidiabetic and Hypolipidemic Effects of Methanol Leaf Extract of Newbouldia laevis in Alloxan Induced Diabetic Rats. Adv Res Gastroentero Hepatol. 2019; 13(3): 555863. DOI: https://doi.org/10.19080/ARGH.2019.13.555863

Chatterjee T., A. Basak, A. Barua, K. Mukherjee, L. Roy, (1979) Studies on the structure and stereochemistry of canthic acid–a new triterpene acid sapogenin from Canthium dicoccum, Trans. Bose Res. Inst. Calcutta 42 (3–4) (1979) 85–88.

Chukwujeku JC, Staden JV, Smith P. (2005) Antibacterial, anti-inflammatory and anti-malarial activities of some Nigerian medicinal plants. SA J Bot. 2005;71(3&4): 316–325. DOI: https://doi.org/10.1016/S0254-6299(15)30105-8

Dzubak P., M. Hajduch, D. Vydra, A. Hustova, M. Kvasnica, D. Biedermann, L. Markova, M. Urban, J. Sarek, (2006) Pharmacological activities of natural triterpenoids and their therapeutic implications, Nat. Prod. Rep. 23 (3) (2006) 394–411. DOI: https://doi.org/10.1039/b515312n

Eyong K.O., H.L. Ketsemen, S.Y. Ghansenyuy, G.N. Folefoc, (2015) Chemical constituents, the stereochemistry of 3-hydroxy furonaphthoquinones from the root bark of Newbouldialaevis Seem (Bignoniaceae), and screening against Onchocercaochengi parasites, Med. Chem. Res. 24 (3) (2015) 965–969. DOI: https://doi.org/10.1007/s00044-014-1173-z

Gafner, S., Wolfender, J.L., Nianga, M. and Hostettmann, K. (1997). Phenylpropanoid Glycosides from Newbouldia laevis Roots. Phytochemistry 44 (4): 687 – 690. DOI: https://doi.org/10.1016/S0031-9422(96)00611-5

George K. Ainooson, Eric Woode, David D. Obiri, George A. Koffour. (2009) Pharmacognosy Magazine 2009, 4, 49-54.

Germann, K., Kaloga, M., Ferreira, D., Marais, J.P. and Kolodziej, H. (2006). Newbouldioside A–C Phenylethananoid Glycosides from the Stembark of Newbouldia leavis. Phytochem 67 (8): 805 – 811. DOI: https://doi.org/10.1016/j.phytochem.2006.01.016

Ghosh T., T.K. Maity, J. Singh, (2011) Evaluation of antitumor activity of stigmasterol, a constituent isolated from Bacopa monnieri Linn aerial parts against Ehrlich Ascites Carcinoma in mice, Orient Pharm Exp Med 11 (1) (2011) 41–49. DOI: https://doi.org/10.1007/s13596-011-0001-y

Gidado, O. G. , Kibou, A. , Gwargwor, Z. A., Mbaya, P. and Baba, M. J. (2003). Assessment of Anti-nutritive factors and nutrient composition of some selected browse plants use as livestock feeds in Taraba state. In: International Journal of Applied Sciences and Engineering. p 5-9

Hussain H., K. Krohn, V.U. Ahmad, G.A. Miana, I.R. (2007) Green, Lapachol: an overview, Arkivoc 2 (1) (2007) 145–171. DOI: https://doi.org/10.3998/ark.5550190.0008.204

Idu M, Obaruyi GO, Erhabor JO. (2009) Ethnobotanical uses of plants among the Binis in the treatment of ophthalmic andENT {Ear, Nose and Throat} ailments. Ethnobotanical Leaflets. 2009;13:480-96.

Iwu, M.M. (2000). Handbook of African Medicinal Plants. CRC Press, Inc. London p. 19.

Josiah Bitrus Habu1 and Bartholomew Okechukwu Ibeh. (2015) In vitro antioxidant capacity and free radical scavenging evaluation of active metabolite constituents of Newbouldia laevis ethanolic leaf extract. Biological Research 2015, 48: DOI: https://doi.org/10.1186/s40659-015-0007-x

Kuete V, Eyong KO, Folefoc GN, Bengi VP, Hussain H, Krohn K, Nkengfack AE. (2007) Antimicrobial activity of the methanolic extract and of the chemical constituents isolated from Newbouldia laevis. Pharmazie. 2007;552-556.

Kumar V., K. Kaur, G.K. Gupta, A.K. Sharma, (2013) Pyrazole containing natural products: synthetic preview and biological signiﬁcance, Eur. J. Med. Chem. 69 (2013) 735–753. DOI: https://doi.org/10.1016/j.ejmech.2013.08.053

Lewis, W.H. and Manony, P.F.E. (1977). Medical Botany: Plants Affecting Man’s Health. John Wiley and Sons. New York, USA p. 240

Ndarubu Tsado A, Jigam AA, Olufunmilola Akanya H, Famous Ossamulu I, Damola Ariyeloye S. (2020) Acute Toxicity Studies and Anti-plasmodial Potentials of Newbouldia laevis and Crateva adansonii in Plasmodium Berghei-infected Mice. Iranian Journal of Toxicology. 2020; 14(2):93-104. DOI: https://doi.org/10.32598/ijt.14.2.636

Oliver-Bever, B. (1986). Medicinal Plants in Tropical West Africa. Cambridge University Press, London. pp. 117-8, 168. DOI: https://doi.org/10.1017/CBO9780511753114

Petronelli A., G. Pannitteri, U. Testa, (2009) Triterpenoids as new promising anticancer drugs, Anti-Cancer Drugs 20 (10) (2009) 880–892. DOI: https://doi.org/10.1097/CAD.0b013e328330fd90

Rao K., T.McBride, J. Oleson, (1968) Recognition and evaluation of lapachol as an antitumor agent, Cancer Res. 28 (10) (1968) 1952–1954.

Rodriguez-Rodriguez, R.; Ruiz-Gutierrez, V., (2010) Functional properties of pentacyclic triterpenes contained in pomace olive oil. In Olives and Olive Oil in Health and Disease Prevention, Elsevier: 2010; pp 1431–1438. DOI: https://doi.org/10.1016/B978-0-12-374420-3.00159-5

Schymanski E.L., J. Jeon, R. Gulde, K. Fenner, M. Ruff, H.P. Singer, J. Hollender, (2014) Identifying Small Molecules Via High Resolution Mass Spectrometry: Communicating Conﬁdence, ACS Publications, 2014. DOI: https://doi.org/10.1021/es5002105

Shukla S., S. Gupta, (2010) Apigenin: a promising molecule for cancer prevention, Pharm.Res. 27 (6) (2010) 962–978. DOI: https://doi.org/10.1007/s11095-010-0089-7

Stefan G, Jean-Iuc, Wolfender Malo, (1998) Antifungal and antibacterial nephtho-quinones from Newbouldia laevis roots. Ecological biochemistry. Proceedings of Global Summit on Medicinal Plants. 1998;1:98–106.

Udeozo I.P., Andrew C.Nwak, Okechukwu P.C. Ugwu and Michael Akogwu. (2014) Anti-inflammatory, phytochemical and acute toxicity study of the flower extract of Newbouldia laevis. Int.J.Curr.Microbiol.App.Sci (2014) 3(3): 1029-1035.

Usman H, Osuji JC. (2007) Phytochemical and in vitro antimicrobial assay of the leaf extract of Newbouldia laevis. African Journal of Tradit. Complement. Altern. Med. 2007; 4(4):476-480. DOI: https://doi.org/10.4314/ajtcam.v4i4.31240

Yamahara J., G. Kobayashi, H. Matsuda, H. Fujimura, (1998) The vasorelaxant effect of evocarpine in isolated aortic strips: mode of action, Eur. J. Pharmacol. 155 (12)(1988) 139–143. DOI: https://doi.org/10.1016/0014-2999(88)90411-6