Tissue Culture Studies in Withania somnifera (L.) Dunal
DOI:
https://doi.org/10.32439/ps.v3i6.95-98Keywords:
Immunomodulation, Neurodegenerative disorders, Anti-microbial, Withanolides, Withaferin, GlycoproteinAbstract
Withania somnifera is an important medicinal herb that has been widely used for the treatment of different clinical conditions. The overall medicinal properties of Withania somnifera make it a viable therapeutic agent for addressing anxiety, cancer, microbial infection, immunomodulation, and neurodegenerative disorders. Biochemical constituents of Withania somnifera like withanolide A, withanolide D, withaferin A and withaniamides play an important role in its pharmacological properties. Proteins like Withania somnifera glycoprotein and lectin like-protein possess potent therapeutic properties like antimicrobial, anti-snake venom poison and antimicrobial. In this review, we have tried to present different pharmacological properties associated with different extract preparations, phytochemical constituents and protein component of Withania somnifera. Future insights in this direction have also been highlighted.
References
Abhyankar, G.A., Chinchanikar, G.S., (1996). Response of Withania somnifera Dunal leaf explants In vitro. Phytomorphology. 46, 249-252.
Bandyopadhyay M., Jha S., Tepfer D., (2007). Changes in morphological phenotypes and withanolide composition of Ri-transformed roots of Withania somnifera. Plant Cell Rep. 26, 599-609 DOI: https://doi.org/10.1007/s00299-006-0260-0
Devi P.U., Sharada A.C., Solomon F.E., Kamath M.S., (1992). In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma 180. Ind. Jour. Exp. Biol. 30, 169-172.
Furmanowa M., Gajdzis-Kuls D., Ruszkowska J., Czarnocki Z., Obidoska G., Sadowska A., Rani R., Upadhyay S.N., (2001). In vitro propagation of Withania somnifera and isolation of withanolides with immunosuppressive activity. Planta Medica. 67, 146-149. DOI: https://doi.org/10.1055/s-2001-11494
George E.F., Hall M.A., De Klerk G.J., (2008). Plant growth regulators II: Cytokinins, their analogues and antagonists. In: George EF, Hall MA, De Klerk GJ (eds) Plant propagation by tissue culture, 3rd edition, Springer, Dordrecht, Netherlands pp. 205-206. DOI: https://doi.org/10.1007/978-1-4020-5005-3_6
Golegaonkar P.G., Kantharajah A.S., (2006). High-frequency adventitious shoot bud induction and shoot elongation of chile pepper (Capsicum annuum L.). In vitro Cell. Dev. Biol. Plant. 42, 341-344. DOI: https://doi.org/10.1079/IVP2006785
Govindraju, B., Ramgopal R., Venugopal R.B., Kiran S. G., Kaviraj C. P., Srinath R., (2003). High frequency Plant Regeneration in Ashwagandha (Withania somnifera (L.) Dunal): An Important medicinal plant. Plant Cell Biotech. Mol. Biology. 4 (1-2), 49-56
Hussain F., Ilahi F.I., (1988). Germination behaviour of Withania somnifera (L.) Dunal. Hamdard. 31, 20-30.
Jaffer H.J, Jawad A.L.M., Saber H.S., Al-Naib A., (1988). Evaluation of antimicrobial activity of Withania somnifera extracts. Fitoterapia. 59, 497-500.
Kavidra N.T., Neelesh C.S., Vaibhav T. Brahma D., (2000). Micropropagation of Centella asiatica (L.) a valuable medicinal herb. Plant Cell Tissue Org. Cult. 62, 175-179.
Kulkarni A.A., Thengane S.R., Krishnamurthy K.V., (2000). Direct shoot regeneration from node, internode, hypocotyls and embryo explants of Withania somnifera. Plant Cell Tissue Org. Cult. 62, 203-209. DOI: https://doi.org/10.1023/A:1006413523677
Misra H.O., Singh S., Kumar S., (1997). Ashwagandha-Withania somnifera cultivation in India. Farm Bull., No. 005, Central Institute of Medicinal and Aromatic Plants, Lucknow.
Mohan R., (2004). Withaferin A is a potent inhibitor of angiogenesis. Angiogenesis. 7, 115- 122. DOI: https://doi.org/10.1007/s10456-004-1026-3
Murashige T., Skoog F., (1962). A revised medium for rapid growth and bioassays with tobacco tissue cultures. Plant Physiology. 15, 473-497. DOI: https://doi.org/10.1111/j.1399-3054.1962.tb08052.x
Nagesh K.S., (2008). High frequency multiple shoot induction of Curculigo orchioides Gaertn: shoot tip v/s rhizome disc. Taiwania. 53, 242-247.
Offord C.A., Tyler J. L., (2009). In vitro propagation of Pimelea spicata R.Br (Thymelaeaceae), an endangered species of the Sydney region, Australia. Plant. Cell. Tiss. Org. Cult. 98, 19-23. DOI: https://doi.org/10.1007/s11240-009-9534-x
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